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Tae Kim

  • Assistant Professor

My research focuses on:

  1. Developing MRI methods to quantify cerebrovascular function and structure
  2. Apply these methods to assess the role of vascular physiology in brain aging and dementia. Of particular interest is the role of altered vascular physiology in the cognitive decline seen in neurodegenerative diseases, such as Alzheimer’s Disease (AD) and vascular cognitive impairment. In addition, the mechanism of how systemic cardiovascular determinants related to AD and related dementias (ADRD) affect cerebrovascular alterations is another topic-of-interest.

    Education & Training

  • PhD in Biophysical Sciences and Medical Physics (2004) from University of Minnesota
Representative Publications
  1. Kim T, Aizenstein HJ, Snitz BE, Cheng Y, Chang YF, Roush RE, Huppert TJ, Cohen A, Doman J, and Becker JT. Tract Specific White Matter Lesion Load Affects White Matter Microstructure and Their Relationships With Functional Connectivity and Cognitive Decline. Front Aging Neurosci. 2021;13:760663. doi: 10.3389/fnagi.2021.760663. eCollection 2021. PubMed PMID: 35185514; PubMed Central PMCID: PMC8848259.
  2. Kim T, Kim SY, Agarwal V, Cohen A, Roush R, Chang YF, Cheng Y, Snitz B, Huppert TJ, Bagic A, Kamboh MI, Doman J, and Becker JT. Cardiac-induced cerebral pulsatility, brain structure, and cognition in middle and older-aged adults. Neuroimage. 2021 Jun;233:117956. doi: 10.1016/j.neuroimage.2021.117956. Epub 2021 Mar 11. PubMed PMID: 33716158; PubMed Central PMCID: PMC8145789.
  3. Lee Y and Kim T. Assessment of hypertensive cerebrovascular alterations with multiband Look-Locker arterial spin labeling. J Magn Reson Imaging. 2018 Mar;47(3):663-672. doi: 10.1002/jmri.25812. Epub 2017 Jul 10. PubMed PMID: 28691308.
  4. Kim T, Lee Y, and Zhao T, Hetherington HP, Pan JW. Gradient-echo EPI using a high-degree shim insert coil at 7 T: Implications for BOLD fMRI. Magn Reson Med. 2017 Nov;78(5):1734-1745. doi: 10.1002/mrm.26563. Epub 2016 Dec 1. PubMed PMID: 27910126; PubMed Central PMCID: PMC6084307.
  5. Kim T, Zhao T, and Bae KT. Enhancement of functional MRI signal at high-susceptibility regions of brain using simultaneous multiecho multithin-slice summation imaging technique. J Magn Reson Imaging. 2016 Aug;44(2):478-85. doi: 10.1002/jmri.25170. Epub 2016 Jan 28. PubMed PMID: 26821385.
  6. Kim T and Kim SG. Temporal dynamics and spatial specificity of arterial and venous blood volume changes during visual stimulation: implication for BOLD quantification. J Cereb Blood Flow Metab. 2011 May;31(5):1211-22. doi: 10.1038/jcbfm.2010.226. Epub 2010 Dec 22. PubMed PMID: 21179068; PubMed Central PMCID: PMC3099637.
  7. Kim T, Masamoto K, Fukuda M, Vazquez A, and Kim SG. Frequency-dependent neural activity, CBF, and BOLD fMRI to somatosensory stimuli in isoflurane-anesthetized rats. Neuroimage. 2010 Aug 1;52(1):224-33. doi: 10.1016/j.neuroimage.2010.03.064. Epub 2010 Mar 27. PubMed PMID: 20350603; PubMed Central PMCID: PMC2883664.
  8. Kim T and Kim SG. Cortical layer-dependent arterial blood volume changes: improved spatial specificity relative to BOLD fMRI. Neuroimage. 2010 Jan 15;49(2):1340-9. doi: 10.1016/j.neuroimage.2009.09.061. Epub 2009 Sep 30. PubMed PMID: 19800013; PubMed Central PMCID: PMC2819732.
  9. Kim T, Hendrich KS, Masamoto K and Kim SG. Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: implication for BOLD fMRI. J Cereb Blood Flow Metab. 2007 Jun;27(6):1235-47. doi: 10.1038/sj.jcbfm.9600429. Epub 2006 Dec 20. PubMed PMID: 17180136.
  10. Kim T and Kim SG. Quantification of cerebral arterial blood volume and cerebral blood flow using MRI with modulation of tissue and vessel (MOTIVE) signals. Magn Reson Med. 2005 Aug;54(2):333-42. doi: 10.1002/mrm.20550. PubMed PMID: 16032688.

Full bibliography: https://www.ncbi.nlm.nih.gov/myncbi/1N9F-qdeikzAK/bibliography/public/

Research Interests
  • CBF
  • BOLD
  • Alzheimer’s disease and related demetias
  • cognitive impairment
  • aging
  • white matter hyperintensities
  • functional connectivity
  • pulsatility
  • perivascular space
  • cardiovascular health
Research Grants

I am supported by R01AG082700.